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cell permeable derivative  (MedChemExpress)


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    MedChemExpress cell permeable derivative
    Cell Permeable Derivative, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell permeable derivative/product/MedChemExpress
    Average 95 stars, based on 22 article reviews
    cell permeable derivative - by Bioz Stars, 2026-03
    95/100 stars

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    Image Search Results


    CaMKII is involved in different adaptations in acute slices. (A) Experimental design. Slices were preincubated for 2 h with CN21 or SCR peptide and drugs were washed out for 2 h (T1 and T2 are the same as for , ). (B) Representative current traces recorded at T1 and T2 in each condition (C) Mean mEPSCs amplitudes at T1 and T2 (left) and overlaid cumulative probability curves for CN21 (center) and SCR (right), including all mEPSCs recorded during each period. Black curves: distributions at T1. Two-way ANOVA with Bonferroni correction for bar plot, random permutations for cumulative probability plots. (D) Same as panel (C) for mEPSCs frequency and interevent interval (IEI). (E) Percent changes in amplitude and decay time for τ r -binned data. Bootstrap with weighted P -values. (F) Average amplitude and decay time percent changes for slow and fast-rising groups. Bootstrap with Bonferroni correction. (G) Amplitude vs. decay time raw changes for CN21 or SCR peptide. Each point corresponds to the average change for τ r bin. Pearson correlation. (H) Frequency histograms (left) for all events recorded at T1 or T2 and probability density curve (right), in SCR condition. (I) τ r -binned frequency percent increase. (J,K) Same as (H,I) , for CN21. (L) Average frequency increase for fast and slow groups, after SCR or CN21. Bootstrap with Bonferroni correction. * p < 0.05. N = 39 neurons (SCR-T1: 11, SCR-T2: 8, CN21-T1: 8, CN21-T2: 12), from 5 rats (1–4 slices per rat).

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Heterogeneous CaMKII-Dependent Synaptic Compensations in CA1 Pyramidal Neurons From Acute Hippocampal Slices

    doi: 10.3389/fncel.2022.821088

    Figure Lengend Snippet: CaMKII is involved in different adaptations in acute slices. (A) Experimental design. Slices were preincubated for 2 h with CN21 or SCR peptide and drugs were washed out for 2 h (T1 and T2 are the same as for , ). (B) Representative current traces recorded at T1 and T2 in each condition (C) Mean mEPSCs amplitudes at T1 and T2 (left) and overlaid cumulative probability curves for CN21 (center) and SCR (right), including all mEPSCs recorded during each period. Black curves: distributions at T1. Two-way ANOVA with Bonferroni correction for bar plot, random permutations for cumulative probability plots. (D) Same as panel (C) for mEPSCs frequency and interevent interval (IEI). (E) Percent changes in amplitude and decay time for τ r -binned data. Bootstrap with weighted P -values. (F) Average amplitude and decay time percent changes for slow and fast-rising groups. Bootstrap with Bonferroni correction. (G) Amplitude vs. decay time raw changes for CN21 or SCR peptide. Each point corresponds to the average change for τ r bin. Pearson correlation. (H) Frequency histograms (left) for all events recorded at T1 or T2 and probability density curve (right), in SCR condition. (I) τ r -binned frequency percent increase. (J,K) Same as (H,I) , for CN21. (L) Average frequency increase for fast and slow groups, after SCR or CN21. Bootstrap with Bonferroni correction. * p < 0.05. N = 39 neurons (SCR-T1: 11, SCR-T2: 8, CN21-T1: 8, CN21-T2: 12), from 5 rats (1–4 slices per rat).

    Article Snippet: The CaMKIIN-derived peptide CN21 fused to the cell-permeable sequence tat ( ; ) and a scrambled control peptide, were obtained from Biomatik (Wilmington, DE, United States).

    Techniques:

    Early CaMKII inhibition abolishes or occludes homeostatic adaptations in different groups of synapses. (A) Overlaid τ r -sorted mEPSC amplitude distributions for each temporal stage and condition. The curve for CN21 at T2 was omitted for simplicity. (B) Amplitude percent differences with respect to the SCR distribution at T1 (C) Same as panel (A) , for decay time. Inset, detail for fast-rising group. (D) Same as panel (B) , for decay time. (E) Superimposed event frequency distributions for each time interval and condition (same curves as in ; left). (F) Frequency increases with respect to SCR condition at T1. Same data as for . Bootstrap with weighted p -values (all panels). * p < 0.05.

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Heterogeneous CaMKII-Dependent Synaptic Compensations in CA1 Pyramidal Neurons From Acute Hippocampal Slices

    doi: 10.3389/fncel.2022.821088

    Figure Lengend Snippet: Early CaMKII inhibition abolishes or occludes homeostatic adaptations in different groups of synapses. (A) Overlaid τ r -sorted mEPSC amplitude distributions for each temporal stage and condition. The curve for CN21 at T2 was omitted for simplicity. (B) Amplitude percent differences with respect to the SCR distribution at T1 (C) Same as panel (A) , for decay time. Inset, detail for fast-rising group. (D) Same as panel (B) , for decay time. (E) Superimposed event frequency distributions for each time interval and condition (same curves as in ; left). (F) Frequency increases with respect to SCR condition at T1. Same data as for . Bootstrap with weighted p -values (all panels). * p < 0.05.

    Article Snippet: The CaMKIIN-derived peptide CN21 fused to the cell-permeable sequence tat ( ; ) and a scrambled control peptide, were obtained from Biomatik (Wilmington, DE, United States).

    Techniques: Inhibition